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Medical Ontology Research

The LHNCBC Medical Ontology Research project encompasses basic research on biomedical terminologies and ontologies and their applications to natural language processing, clinical decision support, translational medicine, data integration and interoperability. In the past few years, our research has focused on the integration, dissemination, quality assurance and applications of drug ontologies (add link to the 2014 BoSC report) and on quality assurance in biomedical ontologies. We also develop application programming interfaces (APIs) and browsers for drug resources including RxNorm, RxTerms, NDF-RT and ATC.

Bodenreider O. Evaluating the Quality and Interoperability of Biomedical Terminologies Technical Report to the LHNCBC Board of Scientific Counselors April 2018
Cui L, Bodenreider O, Shi J, Zhang GQ. Auditing SNOMED CT hierarchical relations based on lexical features of concepts in non-lattice subgraphs. J Biomed Inform. 2017 Dec 20. pii: S1532-0464(17)30280-0. doi: 10.1016/j.jbi.2017.12.010.
Harpaz R, DuMouchel W, Schuemie M, Bodenreider O, Friedman C, Horvitz E, Ripple A, Sorbello A, White RW, Winnenburg R, Shah NH. Toward multimodal signal detection of adverse drug reactions. J Biomed Inform. 2017 Dec;76:41-49. doi: 10.1016/j.jbi.2017.10.013. Epub 2017 Nov 1.
Raje S, Bhupatiraju R, Abdelrahman H, Busby B. MeSHgram: An Open Source Tool to Visually Browse Co-occurrence of MeSH Terms in PubMed [Poster]. AMIA 2017 Symposium Proceedings.
Fung K. Medical Terminologies in Action Technical Report to the LHNCBC Board of Scientific Counselors September 2017
Dhombres F, Bodenreider O. Trends in Fetal Medicine: A 10-Year Bibliometric Analysis of Prenatal Diagnosis. Stud Health Technol Inform. 2017;245:853-857.
Nelsonn SD, Parker J, Lario R, Winnenburg R, Erlbaum MS, Lincoln MJ, Bodenreider O. Interoperability of medication classification systems: Lessons learned mapping estab-lished pharmacologic classes (EPCs) to SNOMED CT. Stud Health Technol Inform. 2017;245:920-924.
Yu Z, Nguyen T, Dhombres F, Johnson T, Bodenreider O. "Hybrid Topics" - Facilitating the Interpretation of Topics Through the Addition of MeSH Descriptors to Bags of Words. Stud Health Technol Inform. 2017;245:662-666.
Raje S, Bodenreider O. Interoperability of disease concepts in clinical and research ontologies – Contrasting coverage and structure in the Disease Ontology and SNOMED CT. Stud Health Technol Inform. 2017;245:925-929.
Bahr NJ, Nelson SD, Winnenburg R, Bodenreider O. Eliciting the Intension of Drug Value Sets - Principles and Quality Assurance Applications. Stud Health Technol Inform. 2017;245:843-847.