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Medical Ontology Research

The LHNCBC Medical Ontology Research project encompasses basic research on biomedical terminologies and ontologies and their applications to natural language processing, clinical decision support, translational medicine, data integration and interoperability. In the past few years, our research has focused on the integration, dissemination, quality assurance and applications of drug ontologies (add link to the 2014 BoSC report) and on quality assurance in biomedical ontologies. We also develop application programming interfaces (APIs) and browsers for drug resources including RxNorm, RxTerms, NDF-RT and ATC.

Publications/Tools: 
Sehgal AK, Srinivasan P, Bodenreider O. Gene Terms and English Words: An Ambiguous Mix Proc of the SIGIR 2004 Workshop on Search and Discovery in Bioinformatics 2004.
Bodenreider O, McCray AT. Exploring Semantic Groups Through Visual Approaches J Biomed Inform. 2003 Dec;36(6):414-432.
Bodenreider O, Zhang S. Semantic Integration in Biomedicine Proceedings of the Semantic Integration Workshop at the Second International Semantic Web Conference. 2003;: 156-157.
Mitchell JA, McCray AT, Bodenreider O. From Phenotype to Genotype: Issues in Navigating the Available Information Resources Methods Inf Med. 2003;42(5):557-63.
Zhang S, Bodenreider O. Knowledge Augmentation for Aligning Ontologies: An Evaluation in the Biomedical Domain Proceedings of the Semantic Integration Workshop at the Second International Semantic Web Conference. 2003: 109-114.
Bodenreider O. The Unified Medical Language System (UMLS): Integrating Biomedical Terminology Nucleic Acids Res; Database Issue. 2004;32: 267-70.
Zhang S, Bodenreider O. Investigating Implicit Knowledge in Ontologies with Application to the Anatomical Domain Altman RB, Dunker AK, Hunter L, Jung TA, Klein TE, editors. Pacific Symposium on Biocomputing 2004: World Scientific. 2004;: 250-261.
Azuaje FJ, Bodenreider O, Wang H, Dopazo J. Gene Ontology-Driven Similarity for Gene Expression Correlation Analysis Proceedings of the second conference on Standards and Ontologies for Functional Genomics (SOFG 2) 2004:47.
Bodenreider O, Smith B, Burugn A. The Ontology-Epistemology Divide: A Case Study in Medical Terminology Proceedings of the Third International Conference on Formal Ontology in Information Systems (FOIS2004): IOS Press; 2004. p. 185-195.
Wang H, Azuaje F, Bodenreider O, Dopazo J. Gene Expression Correlation and Gene Ontology-Based Similarity: An Assessment of Quantitative Relationships Proceedings of the 2004 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB'2004) 2004:25-31.

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