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From Germs to Genes: Trends in Drug Therapy, 1852-2002

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Parascandola J
Pharm Hist. 2002 ;44(1):3-11.
Abstract: 

In spite of the impressive advances made in drug therapy over the past century or so, we have not yet achieved the lofty goals envisioned by Brunton and some of his contemporaries. We still cannot predict the pharmacological action of any compound with certainty by merely inspecting its structural formula, nor can we yet design drugs at will for specific diseases.

Parascandola J. From Germs to Genes: Trends in Drug Therapy, 1852-2002 Pharm Hist. 2002 ;44(1):3-11.