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Automatic Determination of Anti-coagulation Status with NDF-RT

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Bodenreider O, Mougin F, Burgun A
Proceedings of the 13th ISMB'2010 SIG meeting Bio-ontologies 2010:140-143
Abstract: 

Objectives: To determine the anti-coagulation status of patients, based on the list of medications they have been prescribed, using the publicly available resource NDF-RT (National Drug File Reference Terminology). Methods: We explored the legacy VA classes and we refined the definition of external pharmacologic classes (EXT) in NDF-RT in order to enable inferences by a description logic classifier. Results: Of the 9 patients with a positive anti-coagulation status, the VA class approach identified only 6, while the EXT approach identified 8. Conclusions: This preliminary experiment illustrates the benefits of using a refined definition of external pharmacologic classes in NDF-RT. Further investigation is needed. Supplementary figure: Representation of the drug clopidogrel in NDF-RT, available at: http://mor.nlm.nih.gov/pubs/supp/2010-bioonto-ob/index.html.

Bodenreider O, Mougin F, Burgun A. Automatic Determination of Anti-coagulation Status with NDF-RT Proceedings of the 13th ISMB'2010 SIG meeting Bio-ontologies 2010:140-143